Simulation of bioreactors

The tool for modelling, Design of Experiments (DoE) and scale-up

With Module M2 of the BioAssistent fermentations, cell cultures and scale up can be prepared and improved systematically.

  • Reduction of costs for test series and scale-up
  • Enhanced quality of experimental results
  • Acceleration of process development and scale-up

BioAssistent transfers biotechnological processes and plants into realistic simulation models. Therefore it creates a "virtual bioreactor" with the help of which the interaction of biology and plant equipment can be visualised quickly and clearly via a computer. The results obtained this way can be compared directly with experimental results. In addition to that the BioAssistent is characterised by an intuitive operation and an optimised workflow.

Typical areas of application are:

  • Design of experiments (DoE) and scale-up
  • Optimising process control
  • Modelling of bioprocesses and of metabolic pathways
  • Studies on metabolism, metabolic engineering, synthetic biology
  • Education, teaching, training

Simple modelling based on libraries

Task Description
Process
  • A model of biochemical reactions and complex metabolic pathways can be created from existing building blocks and with a simple mouse click – no programming is necessary.
  • All kinetics can be connected with the operation conditions of the bioreactor and the dynamically determined influencing parameters.
  • The substances involved can be retrieved from a library of components.
Plant
  • Realistic “virtual bioreactor” including gas and liquid mass transfer and control loops
Presentation of results
  • Graphic presentation of results with a selection of templates and custom graphics
  • Import function for the import of experimental data
  • Comparative representation of calculated and experimental data
Project administration
  • All settings and results are being saved in a project file and are thus available at the touch of a button.
  • Extendable libraries for processes (metabolism models), bioreactors and substances
  • Process and bioreactors from the library can be combined flexibly.